Simplicef (Cefpodoxime proxetil) Tablets - Pfizer are indicated for the treatment of skin infections (wounds and abscesses) in dogs caused by susceptible strains of Staphylococcus intermedius, Staphylococcus aureus, Streptococcus canis (group G, B hemolytic), Escherichia coli, Pasteurella multocida, and Proteus mirabilis.
Dosage and Administration:
Dose range: The dose range of SIMPLICEF (cefpodoxime proxetil) tablets is 5-10 mg/kg (2.3-4.5 mg/lb) body weight, administered orally, once a day. The dose may be given with or without food. The determination of dosage for any particular patient must take into consideration such factors as the severity and nature of the infection, the susceptibility of the causative organisms, and the integrity of the patient's host-defense mechanisms. Obtain a sample of the pathogenic organism for culture and sensitivity testing prior to beginning antimicrobial therapy. Once results become available, continue with appropriate therapy.
Duration: Cefpodoxime proxetil tablets should be administered once daily for 5-7 days or for 2-3 days beyond the cessation of clinical signs, up to a maximum of 28 days. Treatment of acute infections should not be continued for more than 3-4 days if no response to therapy is seen.
Dosing Charts: For daily oral administration of Cefpodoxime proxetil at 5 mg/kg (Table 1) and 10 mg/kg (Table 2).
Table 1. Dose Table for SIMPLICEF Tablets at 5 mg/kg Total Daily Dosage
|
Weight of Dog (lbs) | ||||||
|
Daily Dose |
|
22 |
44 |
66 |
88 |
132 |
|
No. of 100 mg tablets |
|
0.5 |
1 |
1.5 |
|
1 |
|
No. of 200 mg tablets |
|
|
|
|
1 |
1 |
|
Weight of Dog (kg) | ||||||
|
Daily Dose |
|
10 |
20 |
30 |
40 |
60 |
|
No. of 100 mg tablets |
|
0.5 |
1 |
1.5 |
|
1 |
|
No. of 200 mg tablets |
|
|
|
|
1 |
1 |
Table 2. Dose Table for SIMPLICEF Tablets at 10 mg/kg Total Daily Dosage
|
Weight of Dog (lbs) | ||||||
|
Daily Dose |
11 |
22 |
44 |
66 |
88 |
132 |
|
No. of 100 mg tablets |
0.5 |
1 |
|
1 |
|
|
|
No. of 200 mg tablets |
|
|
1 |
1 |
2 |
3 |
|
Weight of Dog (kg) | ||||||
|
Daily Dose |
5 |
10 |
20 |
30 |
40 |
60 |
|
No. of 100 mg tablets |
0.5 |
1 |
|
1 |
|
|
|
No. of 200 mg tablets |
|
|
1 |
1 |
2 |
3 |
Contraindications:
SIMPLICEF is contraindicated in dogs with known allergy to cefpodoxime or to the b-lactam (penicillins and cephalosporins) group of antibiotics.
Warnings:
Not for human use. Keep this and all drugs out of reach of children. Antimicrobial drugs, including penicillins and cephalosporins, can cause allergic reactions in sensitized individuals. To minimize the possibility of allergic reactions, those handling such antimicrobials, including cefpodoxime, are advised to avoid direct contact of the product with the skin and mucous membranes.
Precautions:
The safety of cefpodoxime proxetil in dogs used for breeding, pregnant dogs, or lactating bitches has not been demonstrated. As with other cephalosporins, cefpodoxime proxetil may occasionally induce a positive direct Coombs' test.
Adverse Reactions:
Vomiting, diarrhea, increased water drinking and decreased appetite can occur.
Storage:How Supplied: Simplicef (Cefpodoxime proxetil) - 100 mg and 200 mg tablets.
Additional information not available for this medicine.