Legend Injectable Solution - 4 ml Vial

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Product Code : P0000000073

Hyaluronate Sodium

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PRODUCT INFORMATION

LEGEND® Injectable Solution is indicated in the treatment of joint dysfunction of the carpus or fetlock in horses due to non-infectious synovitis associated with equine osteoarthritis.

LEGEND delivers proven efficacy

In field studies, overall clinical improvement was judged to be excellent or good in 90% of the cases treated intravenously with LEGEND and 96% of those treated intra-articularly with LEGEND.1
By decreasing the production and release of inflammatory mediators, LEGEND helps reduce joint inflammation and the resulting pain and lameness.2

The interleukin-1-driven production and release of prostaglandin and also the protein count in synovial fluid is decreased for 45 days following I.V. injection, indicating a beneficial effect long after I.V. administration.

The Properties of Hyaluronic Acid (HA)

HA stimulates endogenous HA production.

HA administration stimulates synoviocytes to produce endogenous high-molecular-weight HA.3

HA provides a physical barrier.

HA contributes to the steric exclusion of plasma components and leukocytes.2

HA decreases the presence of inflammatory mediators.

HA decreases the interleukin-1-driven production and release of prostaglandin E2. PgE2 causes cartilage destruction.4 HA scavenges oxygen-derived free radicals.5

 

LEGEND is pure hyaluronic acid

Derived naturally through a unique biofermentation process, LEGEND is pure hyaluronic acid. After biofermentation, LEGEND is purified through a 12-step microfiltration process to remove impurities and foreign proteins. Foreign proteins increase the potential for joint flares.


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